Mammoth Biosciences researchers have developed NanoCas, an ultracompact CRISPR nuclease, demonstrating its ability to perform ...

By Balambal Suryanarayanan CRISPR-Cas9 is a repurposed gene editing tool that allows scientists to cut, replace, and insert pieces of DNA in precise regions along the strand. Courtesy of NIH Image ...

The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

Researchers at Oregon Health & Science University have developed the first transgenic nonhuman primate model—genetically ...

Now, an in vivo protocol facilitates screens in mouse brain, using adeno-associated virus with transposon-based delivery of the CRISPR guide RNAs. Genetic interaction (GI) mapping is a powerful ...

Africa is grappling with severe food insecurity in the wake of consecutive droughts, climate change, and ongoing conflicts, ...

Gene therapies to treat rheumatoid arthritis have evolved slowly, but one is ready to move into human trials and an ...

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UCSF scientists are taking the first steps toward creating a new type of antibiotic that uses an unusual virus to defeat ...

1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

The emerging use of recombinase polymerase amplification (RPA) coupled with CRISPR/Cas12a technology in bacterial diagnostics marks a significant advancement in the field, providing rapid, highly ...

The emergent field of CRISPR/Cas sensing technology is showing promise as a new paradigm in clinical diagnostics, although widespread clinical adoption remains limited. This perspective paper ...