With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which ...

which renders tRCC vulnerable to interventions that promote NADH reductive stress, highlighting how the maintenance of the optimal redox state in cancer can be therapeutically exploited.

RTCB is required for the splicing of both tRNA and XBP1 mRNA, whereas the DDX1 enzymatic activity is specifically required for tRNA splicing in vivo. Snaebjornsson et al. explore a selective ...