The FDA has accepted for review the NDA for bumetanide nasal spray for edema associated with CHF, as well as hepatic and renal disease.

The drug is designed to reduce inflammation in the brain and has been used on MS, cancer and migraine headaches.

But if the end portion of the ileum has been removed, Sandborn says, the vitamin will have to be given as a shot (typically once a month) or an intranasal formulation, such as a nasal spray.