Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis, a phenomenon ...

Glycolysis has reversed from an energy-producing to an energy-consuming process. What's more, the lack of energy further stimulates the production of fructose bisphosphate, creating a vicious circle.

However, a closer look at the biochemical steps of glycolysis provides clarity: the metabolic pathway, which involves many reactions, is divided into two parts. First, the cell has to invest energy to ...