The fatty membrane surrounding every living cell is a vibrant environment where countless biological processes take place.

Researchers try multiple means to get high-quality membrane proteins for X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy studies. As much as 30% of human genes code for ...

Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

It does that by talking to the membrane fusion protein." More information: Chanwoo Lee et al, Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion, Nature ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

A new study shows how an anticancer drug triggers an “outside in” signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism ...

It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins, complex molecules that are essential for all life. Next-generation ...

In humans, there are two protein families of sodium (Na+)-dependent Pi importers, SLC20 and SLC34. A sole Pi exporter has been identified – SLC53A1. The mitochondrial carrier SLC25A2 transports Pi ...