The phase 1 trial is testing the safety tolerability, pharmacokinetics, and pharmacodynamics of PVT201 in healthy volunteers and patients.

The decision to terminate the HYPERION trial reflects a loss of clinical equipoise, making it unethical to continue the placebo-controlled study.

Patients with ATTR-PN have a high rate of comorbidities and substantial direct healthcare and economic burdens, a study found.

EGPA-associated nasal polyposis should be managed with medically (ie, biologics, anti-inflammatory drugs, and topical corticosteroids) and, in some cases, surgery. Nasal polyposis associated with ...

Women who desire to become pregnant should be counseled on the significance of alloimmunization as a substantial risk during pregnancy. A pregnant woman with hemolytic disease of the fetus and newborn ...

Pregnancies affected by multiple alloantibodies had significantly higher antibody titers and an increased need for intrauterine transfusion. Pregnancies complicated by multiple alloantibodies rather ...

In diagnosed cases of cutaneous mastocytosis, investigations to rule out systemic mastocytosis may be appropriate. A young child with a small chest lump and anemia was found to have cutaneous ...

Patients with achondroplasia often require thoracic/thoracolumbar and/or lumbar decompressive surgery due to prevalent spinal stenosis. Patients with achondroplasia undergoing spinal surgery ...

Children with achondroplasia seem to be more challenged in the anterior-posterior direction, which might be linked to an anterior-shifted pelvis. No difference was observed in bipedal static postural ...

Alloimmunization can sometimes be traced to having received a blood transfusion, and can result in the presentation of a wide range of antibodies. Some women with alloimmunized singleton gestations in ...

The physicians observed significant improvement over the next week with epithelization rates beyond 50% by week 7. A case of a patient with a rare combination of myelofibrosis (MF) and pyoderma ...