May 2, 2024 · Abbreviations: AML: acute myeloid leukemia; CCUS: clonal cytopenia of undetermined significance; del: deletion; EB: excess blasts; FISH: fluorescence in situ ...
New Psoriasis Antibody Treatment Shows Exceptional Clinical Results
Dec 24, 2024 · PSORIASIS, a chronic immune-mediated skin condition, poses a significant challenge for patients, with an ongoing unmet need for effective biologic treatments. To address this, a recent randomised clinical trial evaluated the safety, pharmacokinetics, and efficacy of QX004N in both healthy individuals and patients with moderate to …
New CML Treatment Shows Promise, But Standard Therapy Endures
Oct 18, 2024 · The ASC4FIRST trial has shown asciminib, a novel BCR::ABL1 inhibitor, as a promising alternative to current tyrosine kinase inhibitors (TKIs) for chronic phase (CP) chronic myeloid leukaemia (CML). However, experts caution that the study’s design and outcomes raise significant questions, suggesting that imatinib, the original …
EMJ | Elevating the quality of healthcare globally
Data from 22 studies, encompassing 756,088 subjects, including 62,072 Hispanic adults, revealed striking findings.
Why EGFR Exon 21 L858R Mutations Should Be Treated Differently
BACKGROUND. EGFR gene mutations have been reported in 15–60% of non-small cell lung cancers (NSCLCs) with an important difference in prevalence between Eastern and Western populations. 1,2 The most common EGFR-activating mutations in NSCLC include in-frame deletions in exon 19 and a substitution in exon 21 (L858R) which account for 47% and 41%, respectively, of observed EGFR mutations in ...
The Application, Safety, and Recent Developments of Commonly …
Sep 12, 2024 · Gadolinium-based contrast agents (GBCA) have played a pivotal role in enhancing the diagnostic capabilities of MRI for several decades. The application of gadolinium as a contrast agent opened new possibilities for early diagnosis with greater accuracy of a wide range of conditions, including neurologic and vascular disorders, tumours, cancers, inflammation, and …
Pernicious Anaemia: Mechanisms, Diagnosis, and Management
Jan 24, 2020 · INTRODUCTION. Pernicious anaemia (PA) (also known as Biermer’s disease 1 and Addisonian anaemia 2) is a macrocytic anaemia caused by a vitamin B12 (cobalamin) deficiency, which, in turn, is the result of intrinsic factor (IF) deficiency.IF is a glycoprotein that binds cobalamin and thereby enables its absorption at the terminal ileum. 3 Whether the stomach pathogen Helicobacter pylori plays ...
24 CARDIOLOGY • October 2021 EMJ used and accessible diagnostic methods. Patients with HFrEF who experience an improvement in LVEF (≥50%) are now described as having ‘recovered HFrEF’, rather than HFpEF.
- [PDF]
Abstract Highlights
Abstract Highlights EAU 2024 32 Urology May 2024 Creative Commons Attribution-Non Commercial 4.0 Award-Winning Abstract: Optimal Clinical and Cost-Effective Ways to Manage Kidney Stones RENAL tract stones are prevalent, and the European
Emetogenicity of Chemotherapy : MASCC/ESMO Guidelines - EMJ
Jun 16, 2022 · INTRODUCTION. CINV is experienced by about 70–80% of adult patients with cancer who are receiving chemotherapy, decreasing both quality of life and treatment compliance. 1-3 CINV remains one of the most feared side effects of chemotherapy, despite the availability of new and effective antiemetic medications. 4,5 With appropriate prophylaxis, vomiting can now be prevented in most patients ...